• benoit busser

Breaking News ! Read our latest work just published in Advanced Science !

Breaking News ! Just published in Advanced Science ! Read our latest work in which we used #LIBS elemental imaging to localize rare-earth nanoscintillators (LaF3:Ce) in brain tumors (#glioblastoma). Great collaboration with Anne-Laure Bulin (INSERM / ESRF), Hélène Elleaume (INSERM / ESRF), and Lucie Sancey (Institute for advanced Biosciences)



Details about this article:


Title:

Radiation Dose‐Enhancement Is a Potent Radiotherapeutic Effect of Rare‐Earth Composite Nanoscintillators in Preclinical Models of Glioblastoma (Original Article)


Authors:

Anne‐Laure Bulin

Mans Broekgaarden

Frédéric Chaput

Victor Baisamy

Jan Garrevoet

Benoît Busser

Dennis Brueckner

Antonia Youssef

Jean‐Luc Ravanat

Christophe Dujardin

Vincent Motto‐Ros

Frédéric Lerouge

Sylvain Bohic

Lucie Sancey

Hélène Elleaume


Abstract


To improve the prognosis of glioblastoma, innovative radiotherapy regimens are required to augment the effect of tolerable radiation doses while sparing surrounding tissues. In this context, nanoscintillators are emerging radiotherapeutics that down‐convert X‐rays into photons with energies ranging from UV to near‐infrared. During radiotherapy, these scintillating properties amplify radiation‐induced damage by UV‐C emission or photodynamic effects. Additionally, nanoscintillators that contain high‐Z elements are likely to induce another, currently unexplored effect: radiation dose‐enhancement. This phenomenon stems from a higher photoelectric absorption of orthovoltage X‐rays by high‐Z elements compared to tissues, resulting in increased production of tissue‐damaging photo‐ and Auger electrons. In this study, Geant4 simulations reveal that rare‐earth composite LaF3:Ce nanoscintillators effectively generate photo‐ and Auger‐electrons upon orthovoltage X‐rays. 3D spatially resolved X‐ray fluorescence microtomography shows that LaF3:Ce highly concentrates in microtumors and enhances radiotherapy in an X‐ray energy‐dependent manner. In an aggressive syngeneic model of orthotopic glioblastoma, intracerebral injection of LaF3:Ce is well tolerated and achieves complete tumor remission in 15% of the subjects receiving monochromatic synchrotron radiotherapy. This study provides unequivocal evidence for radiation dose‐enhancement by nanoscintillators, eliciting a prominent radiotherapeutic effect. Altogether, nanoscintillators have invaluable properties for enhancing the focal damage of radiotherapy in glioblastoma and other radioresistant cancers.


DOI : https://onlinelibrary.wiley.com/doi/full/10.1002/advs.202001675


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